Banner image

Publications

List of selected publications and research outputs can be listed here with links and short summaries.

The CD133 and CD34 cell types in human umbilical cord blood have the capacity to produce infectious dengue virus particles.

Amrita Vats, Tzu-Chuan Ho, Irwin Puc, Chiung-Hsin Chang, Guey-Chuen Perng & Po-Lin Chen

We showed that CD34⁺/CD133⁺ UCB cells support persistent DENV infection (up to 30 days) with productive and latent phases, retaining the ability to reactivate and transmit infectious virus.

Mobilization of Hematopoietic Stem and Progenitor Cells during Dengue Virus Infection

Irwin Puc, Tzu-Chuan Ho, Yu-Wen Chien, Sia-Seng Tan, Yu-Cin Fong, Yi-Ju Chen, Sheng-Hsuan Wang, Yun-Hsuan Li, Chun-Hong Chen, Po-Lin Chen, Guey-Chuen Perng, Jih-Jin Tsai

We provided new insight and evidence that DENV infection can induce HSPC mobilization, also that the mobilized HSPCs were not only permissive to DENV infection, but infectious DENV could be recovered after coculture.

Antrodia cinnamomea Suppress Dengue Virus Infection through Enhancing the Secretion of Interferon-Alpha

Yi-Ju Chen, Yu-Cian Tsao, Tzu-Chuan Ho, Irwin Puc, Chia-Chang Chen, Guey-Chuen Perng and Hsiu-Man Lien

We provide new insights into the potential use of A. cinnamomea extracts as therapeutic agents against DENV infection.

Evidence that hematopoietic stem cells in human umbilical cord blood isinfectable by dengue virus: proposing a vertical transmission candidate.

Amrita Vats, Tzu-Chuan Ho,Irwin Puc, Yi-Ju Chen, Chiung-Hsin Chang, Yu-Wen Chien, Guey-Chuen Perng

We showed that CD133⁺/CD34⁺ cells in umbilical cord blood may act as viral reservoirs that amplify DENV and contribute to vertical transmission.

Cytokine Signature of Dengue Patients at Different Severity of the Disease

Irwin Puc, Tzu-Chuan Ho, Ko-Lun Yen, Amrita Vats, Jih-Jin Tsai, Po-Lin Chen, Yu-Wen Chien, Yu-Chih Lo, Guey-Chuen Perng

In this study, we screened 23 cytokines from 243 patient sera across different dengue disease severities. The results reveal cytokine storm and immune dysregulation, with IL-10 and CD121b as potential biomarkers for diagnosis and disease severity prediction.